Machine learning for drug sensitivity prediction and signature gene

Question

[qudrat.nii]

Hello,

I have 800 cell line RNA-Seq with drug sensitivity AUC and IC50 value. I want to design a machine-learning method to find signature genes for drug sensitivity.

Please help me.

Thank you

[Ram]

I want to design a machine-learning method to find signature genes for drug sensitivity.

Why? What have you done so far and where exactly are you stuck?

[qudrat.nii]

we have designed a new drug, and we want to see the signature genes contributing to the sensitivity of the drug. Based on that, we can decide the type of cancer and drug combination.