Pymol semaglutide structure

Question

[Hansen_869]

Hi,

I can't seem to find semaglutide as a pdb structure anywhere, how would one go about modelling it myself?

Thanks!

Answer 1

[Joe]

https://pdb101.rcsb.org/global-health/diabetes-mellitus/drugs/incretins/drug/semaglutide/semaglutide

https://www.rcsb.org/structure/7ki0

You can delete the non-semaglutide structures in this PDB to just get the peptide itself

[Hansen_869]

Thanks, but it doesn't look complete. I struggle to find the C18 diacid and the linker in the PDB.

[Joe]

If its the actual structure of the mimic, and not the peptide itself you want, I would imagine that may well not be in PDB if it has non-natural modifications.

You might have to try other databases or made the modifications yourself. Not my area of expertise though.

[Hansen_869]

I need the complete structure with linker and diacid.Yes, me neither, hence I hope someone can nodge me in the right direction.