Modeling/simulations using SNPs data

Question

[Gonzalo]

Hi there! I’m working with guanacos (Lama guanicoe) and I want to evaluate the effect of hunting on genetic diversity (SNPs). According to my data, the effect of hunting (around 2,000 individuals per year) between the 2005 and 2023 samples is minimal and non-significant. Now, I want to create a simulation/model using MCMC (someone recommended ABC) to assess the impact on genetic diversity over the next 100 years using my SNP data from 2005. As I’m new to this field, I’m not sure how to approach this, and I’m looking forward to any guidance or perspective you can provide on how to tackle this problem.

Answer 1

[Dave Carlson]

I would recommend looking into using SLiM for forward-time population genetic simulations. It's widely used and very well documented, with a variety of recipes for common scenarios. That said, it's pretty different from ABC, so I'm not certain if it's applicable to your case or not.