Tool:VUSkb, one place to triage VUS with ACMG evidence, literature, and ClinVar alerts: feedback welcome!

Question

[Sana]

Hi everyone, I’m part of the Vgenomics team that built VUSkb (vuskb.com). We created it to reduce the time spent jumping across browsers/spreadsheets when classifying variants of uncertain significance (VUS) in clinical and research workflows.

What it does (in brief):

1. Aggregates evidence from 50+ sources (e.g., OMIM, ClinVar, UniProt, PDB, KEGG, dbSNP) into a single record.
2. Applies ACMG/AMP guidance with explainable steps and source tracebacks.
3. Runs real-time ClinVar surveillance with automated alerts so you don’t miss reclassifications.
4. Adds literature mining beyond ClinVar (PubMed) and shows sequence/structure impact with 20+ in silico tools.

Current coverage: 2.11M VUS across 18,511 genes and 25,090 diseases.

I’d love feedback on any must-have things we’re missing for your use case.

Link: vuskb.com (public site; no tracking). Happy to answer technical questions here and incorporate suggestions.