If you sit in the intersection of “likes Australian Rules football / finds sport statistics interesting / is on Twitter”, you’ve probably come across Swamp. One of his recent tweets tells us that: The answer to that question is at once surprising, less surprising when you think about it, and quite easy to figure out … Continue reading Using R/fitzRoy to ask: how many times a V/AFL team with the same lineup has played together?
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“As a rule, theologians know nothing of this world, and far less of the next; but they have the power of stating the most absurd propositions with faces solemn as stupidity touched by fear.”“It is a part of their business to malign and vilify the Voltaires, Humes, Paines, Humboldts, Tyndalls, Haeckels, Darwins, Spencers, and Drapers, and to bow with uncovered heads before the murderers, adulterers, and persecutors of the world. They are, for the most part, engaged in poisoning the …
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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Element Biosciences is launching their AVITI sequencing system today in a blitz of events. At February’s end they flew me out to visit their San Diego facility and gave me quite amazing access to senior staff, Board of Directors members for an entire day of discussions. They even videotaped me! Many of those discussions got deep into technical weeds in a most enjoyable manner. But for those wishing to jump straight to key details, AVITI is a desktop instrument priced …
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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High-throughput sequencing has accelerated human genetics research in countless ways, from rapid newborn sequencing to Mendelian disorders to the many discoveries being made in common, complex disease cohorts. Yet one of the most fundamental benefits of this technology is our ability to catalogue human genetic variation in large cohorts of individuals. For a long while, […] The post Origins and Cautions for the gnomAD Database appeared first on KidsGenomics.
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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A bizarre incident happened on Twitter yesterday. Someone contemplating using Oxford Nanopore to sequence a large, complex genome on a tight budget was asking technical questions about whether to optimize their libraries for overall yield or long inserts, and was getting useful advice from some of the top academic scientists who have propelled ONT forward. One of them suggested using Circulomics products, and that was followed by an ominous yet vague warning from an ONT employee. But not just any …
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Seattle-based single cell analysis firm Parse Bio is announcing this morning a $41.5M Series B round of funding, pushing their total raise just over $50M. Parse uses chemical fixation to lock biomolecules onto their enclosing cells or nuclei, which can then be manipulated without releasing their contents. This enables a series of split-label-pool operations to tag the molecules of interest with barcodes so that in the end each cell has a unique barcode. The protocol requires no specialized instrument, enables …
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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A recent opinion piece titled “A decade of molecular cell atlases” by Stephen Quake narrates the incredible single-cell genomics technology advances that have taken place over the last decade, and how they have translated to increasingly resolved cell atlases. While the article tells some fascinating stories (apparently when hearing a report about the CZI mouse […]
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PacBio CEO Christian Henry was kind enough to chat with me by videoconference just after JP Morgan. To get the the obvious issue out of the way, let me say that while it is common to agree to meet with interview subjects at some future date when they are in Boston, he is the first one to suggest he would just stop by my desk and we'd head to a break room. Henry sits on my employer's board, so if …
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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If you love a good mystery, let me try to draw you in to the enigma of Genapsys' business strategy. Genapsys presented last week at J.P. Morgan, but nobody who wasn't there knows what they said or presented. Keeping their future plans hush-hush is a strange course for a company that hasn't caught fire and is about to face multiple well-funded new competition.Read more »
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Illumina's J.P. Morgan presentation was largely focused on various applications of their platform. But on the further platform development side, they did throw out two new products as very, very limited descriptions: Chemistry X as the future of sequencing-by-synthesis and Infinity for 10 kilobase synthetic reads. Both have triggered a lot of speculation and indeed some very clever sleuthing, since neither really had anything but the faintest of details providedRead more »
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To my readers: I am quite embarrassed by the multiple errors which were present in the first two postings of the year, which include incomplete sentences in jumbled paragraphs, small but key errors of fact and writing "short read" in a key place where I meant "long read'. They are the sort of errors I can be quite harsh on others making. I put too much emphasis on pushing these out and far, far too little on proofreading and reviewing …
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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Some of the (many) recent advances in genetic testing are in the area of non-invasive prenatal testing, or NIPT. This form of genetic screening utilizes the blood of an expecting mother to screen for chromosomal abnormalities and other rare disorders in the fetus. It’s an area of intensive research at the moment, and also the […] The post Prenatal testing, rare diseases, and the New York Times appeared first on KidsGenomics.
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Theral Timpson hosted PacBio CEO Christian Henry and Invitae CEO Sean George for a Mendelspod podcast back on Pearl Harbor day last month. It's a fun, chatty interview with the two which illustrated why these two companies have an excellent strategic fit. I won't summarize all of it, but I did have strong reactions to three pointsRead more »
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It looks like 2022 might be an exciting year for the short read genomics market, with new players taking on Illumina. J.P. Morgan will be virtual next week, so perhaps some of the players will make some announcements. Here's some thoughts on the situation as it stands now in a space where many of failed before -- QIAGEN, ThermoFisher (SOLiD) and Roche(454) -- as well as some have bailed out before even entering -- Agilent.Read more »
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The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed...
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As the year closes out for me (as I write this, it may well have closed out for some of you!) I'm reflecting on some anniversaries that were concentrated in this year, particularly those that are multiples of an early evolutionary developmental decision millions of years ago.Read more »
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It’s almost Christmas, I haven’t posted anything in a while and I see that WordPress has an Image Compare feature, so let’s have some colourful fun. When I’m not at the computer writing R code, I can often be found at the computer processing photographs. Or at the computer browsing Twitter, which is how I … Continue reading Enhancement of old colour photographs using Generative Adversarial Networks
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Oxford Nanopore held their annual Community Meeting online at the beginning of this month. As is typical for this stage of the ONT news cycle, most topics were confirmations and updates of earlier projections, with little brand new material. There was one surprise, a new concept for running nanopore with little to no auxiliary lab equipment. Oh, and perhaps in the surprise category is Oxford appears to be finally moving away from the R9 pore which has been their mainstay …
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Following a silly letter from Scotland, I found it necessary to state very, very clearly that all the opinions expressed in this blog are my own and do not represent the views of either my academic employer or the current Secretary of the Flat Earth Society.
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