Moderator: Chris Miller

gravatar for Chris Miller
Chris Miller19k
Reputation:
18,910
Status:
Trusted
Location:
Washington University in St. Louis, MO
Website:
http://www.chrisamille...
Scholar ID:
Google Scholar Page
Last seen:
5 hours ago
Joined:
7 years, 10 months ago
Email:
c***********@gmail.com

I work in the Genome Institute at Washington University in St. Louis, where I lead a group that develops and applies computational tools to give us insight into the origins and progression of cancer.

Posts by Chris Miller

<prev • 1,015 results • page 1 of 102 • next >
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Answer: A: ExAC includes WES of phenotyped population
... Sure - ExAC is useful for lots of things, but it is not designed to be a control for common disease studies. That requires sequencing a well-phenotyped cohort of individuals known to be negative for your trait of interest. ...
written 5 hours ago by Chris Miller19k
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Comment: C: hey, can someone help me with python?
... Biostars is not a forum for providing homework answers. If this is not homework, and you've put together something that failed, then try another post that shows what you've tried and why it fails and we may be able to help point you in the right direction. Best of luck. ...
written 1 day ago by Chris Miller19k
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Answer: A: R package information
... Have you tried the instructions here to install from github (found on the first page of google results)? https://github.com/jtleek/genstats/issues/5 source("http://bioconductor.org/biocLite.R") biocLite("devtools") # only if devtools not yet installed devtools::install_github('RSkittl ...
written 7 days ago by Chris Miller19k
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Comment: C: Bioinformaticist or bioinformatician?
... This has been discussed previously- closing ...
written 9 days ago by Chris Miller19k
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Comment: C: gunzip file.fastq.gz is not working
... We've all been there - you're not an idiot! ...
written 11 days ago by Chris Miller19k
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Comment: C: Number of Threads for BWA MEM
... +1 - for most setups, alignment will be I/O bound before any other bottleneck gets hit. ...
written 12 days ago by Chris Miller19k
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Comment: C: N in fastq data
... each fastq line has a length (for example, 100 bp). multiply that by the number of fastq entries and that's how many bases of sequence you have. Only after you align the data do you have the ability to talk about sequence coverage across the genome. Seriously, though - There are many resources exp ...
written 14 days ago by Chris Miller19k
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Answer: A: N in fastq data
... I think you have some fundamental misunderstandings about how fastq files and sequencing work. You can have any number of short reads from a genome stored in a fastq file. That has no relationship to how large your target genome is. And yes, aligners will generally handle Ns appropriately. ...
written 14 days ago by Chris Miller19k
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Comment: C: How to do DMR analysis with BiSeq (for RRBS methylation data)?
... This does not answer your BiSeq question directly, but I've been very happy using metilene for DMR calling. ...
written 16 days ago by Chris Miller19k
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Comment: C: Memory-Efficient Way To Transpose Csv/Text File?
... That script explicitly reads the entire file into an array up front, so no, it is not memory-efficient and doesn't answer the question. ...
written 16 days ago by Chris Miller19k

Latest awards to Chris Miller

Oracle 5 weeks ago, created more than 1,000 posts (questions + answers + comments).
Good Answer 6 weeks ago, created an answer that was upvoted at least 5 times. For A: Should I Remove The Unmapped Reads From My Bam ?
Appreciated 6 weeks ago, created a post with more than 5 votes. For C: Should Biostar Be Switched Over To The Stackexchange Network?
Teacher 6 weeks ago, created an answer with at least 3 up-votes. For A: Music Smashing The Stack
Scholar 7 weeks ago, created an answer that has been accepted. For A: Spliting a dataframe based in a chromosome
Scholar 9 weeks ago, created an answer that has been accepted. For A: Spliting a dataframe based in a chromosome
Commentator 10 weeks ago, created a comment with at least 3 up-votes. For C: All Possible Substitutions In The Human Reference Genome
Teacher 10 weeks ago, created an answer with at least 3 up-votes. For A: Music Smashing The Stack
Good Answer 10 weeks ago, created an answer that was upvoted at least 5 times. For A: Any Experiences/Solutions For Problems With The Last R Update?
Appreciated 10 weeks ago, created a post with more than 5 votes. For C: Should Biostar Be Switched Over To The Stackexchange Network?
Teacher 10 weeks ago, created an answer with at least 3 up-votes. For A: Music Smashing The Stack
Scholar 10 weeks ago, created an answer that has been accepted. For A: Spliting a dataframe based in a chromosome
Teacher 12 weeks ago, created an answer with at least 3 up-votes. For A: Can Anyone Suggest Me A Script Based Pipeline For Exome Sequencing With Paired E
Scholar 12 weeks ago, created an answer that has been accepted. For A: Can Anyone Suggest Me A Script Based Pipeline For Exome Sequencing With Paired E
Teacher 3 months ago, created an answer with at least 3 up-votes. For A: Why Should I Use Galaxy ?
Teacher 3 months ago, created an answer with at least 3 up-votes. For A: Music Smashing The Stack
Scholar 3 months ago, created an answer that has been accepted. For A: Spliting a dataframe based in a chromosome
Good Answer 4 months ago, created an answer that was upvoted at least 5 times. For A: Any Experiences/Solutions For Problems With The Last R Update?
Scholar 4 months ago, created an answer that has been accepted. For A: Spliting a dataframe based in a chromosome
Good Answer 4 months ago, created an answer that was upvoted at least 5 times. For A: Difference Between Somatic And Germline Variant Calling?
Popular Question 5 months ago, created a question with more than 1,000 views. For Cancer Genomics/Genomic Medicine - The Genome Institute at WUSTL
Popular Question 5 months ago, created a question with more than 1,000 views. For Will Picard MarkDuplicates also un-mark duplicates?
Appreciated 5 months ago, created a post with more than 5 votes. For C: Should Biostar Be Switched Over To The Stackexchange Network?
Appreciated 6 months ago, created a post with more than 5 votes. For C: Should Biostar Be Switched Over To The Stackexchange Network?
Epic Question 7 months ago, created a question with more than 10,000 views. For Bioinformatics "Cheat Sheet"

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