First I apologize if this is not the kind of question this forum is intended for.
DNA assembly area is an interdisciplinary field involving biology and computer science.
DNA assembly: The process of putting fragments of DNA that has been sequenced into their correct chromosomal positions. The pieces of DNA are assembled to reconstitute the sequence of the chromosome from which they came.
DNA sequence assembly is one of the most popular problems in molecular biology. DNA sequence assembly refers to aligning and merging fragments of a much longer DNA sequence in order to reconstruct the original sequence. There are many solutions provided by researchers.
Question: what is advantage and benefit of DNA assembly for the life in the viewpoint of health and medicine?
Does they have the same meaning : ("genome" and "DNA assembly"). I had doubts. I search about benefit of DNA assembly. But I didn't find result? But I find result about benefit of genome.
Not exactly. For example, E.coli bacteria genome is found to be a circular DNA molecule, 4.6 million bp in length. This Genome is extracted and send out to sequencing center to break into shorter fragments. Different technologies shear the long DNA into short fragments called "reads". These reads are the ones which are assembled back, which is termed a DNA assembly. The DNA assembly is a computational technique which facilitates the genome reconstruction. Ideally, if the DNA assembly produces just 1 long contig of 4.6 million bp, that DNA assembly is perfect.
So, the benefit of DNA assembly is, it helps the researchers to reconstruct genome. The DNA assembly becomes much more tougher for higher organisms like plants, humans because of the size of the genome and repetition. Hope this helps you.
Good explanation. Just to clarify: Genome = biological entity. Sequence assembly = what we have in our computers.