Create distance matrix object from input alignment in BioPython

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7.9 years ago

jba462 ▴ 10

In Biopython, is there a way to create a distance matrix (i.e. a distance matrix 'object' that could be read and manipulated), using an alignment as input?

The "distancematrix" method in Bio.Cluster is giving me problems (ValueError: data has incorrect rank (1 expected 2)) when reading in an alignment file using Cluster.read(), and it won't accept a Numpy array either.

I realize there there is likely an easy solution to this problem, but I've spent the better part of today trying to find an easy way to even calculate the distance between two aligned, amino acid sequences using Biopython.

alignment software-error distance-matrix Biopython • 4.7k views

ADD COMMENT • link updated 7 months ago by Ram 37k • written 7.9 years ago by jba462 ▴ 10

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I think we have an open issue on better distance matrix support on the old (RedMine) Biopython issue tracker, but that is currently offline, probably https://redmine.open-bio.org/issues/2034 (link not tested). See also http://lists.open-bio.org/pipermail/biopython/2006-June/003107.html

ADD REPLY • link 7.9 years ago by Peter 6.0k

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