building a phylogenetic tree with antibody protein sequences

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9.5 years ago

jellevandewege ▴ 120

Hi

I am trying to build a phylogenic tree with antibody protein sequences. The data I got are the same antibody sequences of various cells. The consequence is that there are mutation in the sequences. I want to compare it to the germline and create a tree to visualize the divergence between the sequences and the germline. Is there any software were I can input the protein sequences and germline to see the divergence to get a phylogenic tree?

Thanks!

antibody phylogenic-tree • 3.5k views

ADD COMMENT • link updated 2.2 years ago by Ram 43k • written 9.5 years ago by jellevandewege ▴ 120

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I've heard about the IgTree software with almost the same functionality as you've described. Still I haven't found a link to download it :)

ADD REPLY • link updated 2.2 years ago by Ram 43k • written 9.5 years ago by mikhail.shugay 3.5k

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Thanks!!! its exactly what I was looking for. Unfortunately I could not find a download as well.

ADD REPLY • link 9.5 years ago by jellevandewege ▴ 120

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You can access the IgTree under MTA, you will have to send a request to senior author of the IgTree paper to get the tool..

ADD REPLY • link 9.3 years ago by GP ▴ 10

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