using INRICH with canine data

Question

[labaker518]

I am a newbie so bear with me! We have done a GWAS of a disease using a canine model. We would like to do gene set enrichment testing using INRICH. INRICH requires 4 files:

1. A gene reference file (a human file is provided)
2. A SNP reference file (generated from GWAS data)
3. Gene database you want to look at (human databases are available)
4. The regions identified in your GWAS

If I convert my regions to "human" using the LiftOver tool, I can use the human gene reference file and the human gene databases, but I'm wondering what to do about the SNP reference file. Since it was made with canine data, the names and locations of the SNPs will be from canfam 2.0. Is it valid to use the human SNP map file provided with the test data? I can't quite figure out the purpose of this file.

I have considered not converting my data to human, but I cannot find a comprehensive list of genes across the canine genome similar to the human file provided. The tutorial says you can make your own, but how would I even begin to do that? (This file needs the start and end positions of each gene, so I cannot just use the human file with canine data).

Does anyone have any experience with this that may be able to help guide me?

Lauren