Off topic:What are the advantages of using cell-lines over tissue samples of RNA-seq data ?

Question

[murali]

Hi,

I am working on the cancer samples, it includes the both cell-line samples as well as tissue samples of rna-seq data, and task is to identify differentially expressed genes.

What are the advantages of cell-line samples in contrast to tissue samples?

Please share any papers or articles can explain about advantages of cell-lines?