Design matrix and contrast

Question

[Na Sed]

Hello everyone,

I'd like to use ROAST for analysis of gene sets from "limma" package.

In its input, there is "design matrix" and contrast. Actually, I didn't understand what they are (I am not statistician). Does anyone know a good and simple reference about them?

Thanks.

Answer 1

[Na Sed]

I have found some useful stuff here.