how to select a threshold for Mutual Information value

Question

[nazaninhoseinkhan]

Hi all,

I am trying to plot a gene regulatory network for a bacterium.

I used Aracne in R to do this, but the number of non zero values obtained by Aracne were very few, so I decided to work on its Mutual Information Matrix. I used different thresholds, 0.001, 0.01, 0.05, 0.07 and 0.1.

For thresholds 0.001 and 0.01 number of non-zero values were huge.

My question is what criteria must be taken in to account in threshold selection in Mutual Information

Regards
Nazanin