How to interpret mutation mapper in CBioportal for mutation?

Question

[mangfu100]

Hi all.

I have detected somatic mutation and would like to know its significance for clinical interpretation.

I used MutationMapper in cBioPortal and then got a set of annotated mutations with plot as shown in below.

As you can see, there are a protein domains in the plot with yellow color and all the mutations are on its domain.

and my questions is below:

The segments that do not belong to yellow domains whose color is grey have no meaning for clinically annotating mutation? so I discard it unconsciously?

Answer 1

[Sean Davis]

Your question is an important one without a definitive answer. In terms of clinical annotation, protein domain is just one of MANY, MANY potential features for prioritization. In practice, I would not discard mutations that are not in a known domain.