**3.1k**wrote:

I have two sequences which used to be identical. During time they experienced several mutations, insertions or deletions. I would like to count time that passed.

I read about:

T=k/2r, where k=divergence, r=substitution rate, T=time

However, I read very ambiguous information about human mutation rate (I am interested mostly in mutation rate in retrotransposons) and about the calculation formula (there are many and many).

I would like to start with something really simple at the beginning.

Could you please advice me how to do it, supposing I have two sequences and substitution rate? Or some literature considering this topic? In many articles there stands just "we calculated" instead of exact formula.

Thanks a lot.