Disease diagnosing from a list of detected variants

Question

[Hali]

Hi all,

I am trying to predict risk factors of possible diseases that a person may have from a list of detected variants / genotypes. At the moment, for a single variant, I can find its clinical significance from Clinvar, or GWAS. However, a combination of several variants may cause a different potential risk for a disease. Can someone guide me some strategies to deal with this issue?

Thanks a lot