Tumor normal microarray data analysis
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5.9 years ago
vinaycm911 • 0

How to do comparision for tumors vs normal from different patients without taking average expression values using limma. How to find differentially expressed genes from 10 tumors and 5 normal from different patients?

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Err, it'd be helpful if you clarified your experiment. Are the tumor/normal samples from the same patients (e.g., 5 patients each with 2 tumour biopsies and one normal tissue sample) or are these from 15 different patients? What is your objection to calculating group differences?

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All 15 samples from different patients. Individual patient with one tumor.

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Then you need to use an average, since the results are otherwise meaningless.

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