Question: Tumor normal microarray data analysis
0
gravatar for vinaycm911
4.0 years ago by
vinaycm9110
India
vinaycm9110 wrote:

How to do comparision for tumors vs normal from different patients without taking average expression values using limma. How to find differentially expressed genes from 10 tumors and 5 normal from different patients?

R • 1.1k views
ADD COMMENTlink written 4.0 years ago by vinaycm9110
1

Err, it'd be helpful if you clarified your experiment. Are the tumor/normal samples from the same patients (e.g., 5 patients each with 2 tumour biopsies and one normal tissue sample) or are these from 15 different patients? What is your objection to calculating group differences?

ADD REPLYlink written 4.0 years ago by Devon Ryan90k

All 15 samples from different patients. Individual patient with one tumor.

ADD REPLYlink written 4.0 years ago by vinaycm9110
2

Then you need to use an average, since the results are otherwise meaningless.

ADD REPLYlink written 4.0 years ago by Devon Ryan90k
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