I cannot find any server or tool, which can easily query large number of deleterious score with UniProt sequence and mutations.
The query can be like P04217, p.His52Arg. I have tried dbNSFP, but I found that this database only covers about 60% proteins. Is there any available tools could be helpful? I think methods like SIFT and PolyPhen are necessary for the query results.
Thanks for the help!