This is my first time performing chip-seq analysis. I would like to use SICER to identify enriched domains from histone modification data. One of the input parameters that SICER requires is the fragment size. From the manual:
Fragment size: is for determination of the amount of shift from the beginning of a
read to the center of the DNA fragment represented by the read.
FRAGMENT_SIZE=150 means the shift is 75.
How can I calculate the fragment size?