Different qualities of genomes - Is there a standard/definition?
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9.4 years ago
mschmid ▴ 180

There are different terms for the quality/status of a genome assembly. Like "draft genome", "finished genome" or "high quality genome".

For the case of bacteria I am interested in any standard/"official" definition of quality standards. I basically understand the meaning of the definitions above. But I would like to have a source where I can find an overview of this kind of definitions (what else is commonly used?) and what they are supposed to describe. As already stated, I am mainly dealing with bacteria, so the definitions would ideally apply to bacteria.

genome • 2.3k views
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9.4 years ago
Fidel ★ 2.0k

Check the Sequence ontology. They have a controlled vocabulary for the qualities of the genomes.

For the term 'whole_genome_sequence_status' you find definitions for the following children:

noncontiguous_finished (SO:0001490)
high_quality_draft (SO:0001487)
standard_draft (SO:0001486)
improved_high_quality_draft (SO:0001488)
finished_genome (SO:0001491)
annotation_directed_improved_draft (SO:0001489)
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9.4 years ago
GenoMax 147k

See this paper from Science: https://www.sciencemag.org/content/326/5950/236.full Authors include people who primarily work with bacteria so the definitions should be applicable widely.

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