Thank you for your insights. The best thing I had in mind so far concerning a larger term database was indeed the MeSH DB. Concerning a "perfect" ontology. i.e. in the sense of a non-overlapping one, this is of course unrealistic, because e.g. biological structures interact with their environment in a nonlinear fashion and thus their properties may evoke different terminologies through different viewpoints. Not to speak of evolution.
Still, there should be an easily accessible search, answering queries in the form of a dictionary-esque phrase with references and not in the form of a db nodemap.
Example query: (What is a) "driver gene" (?)
Answer is given implicitly in some paper (not dictionary-ready):
"Cancer is a disease of the genome. As cancer initiates and progresses, genomic instability develops and abnormal genomic changes (e.g., sequence mutations, aberrant promoter methylation, and structural lesions such as gains/losses, inversions and translocations) accumulate. While some of these abnormalities disrupt normal cellular processes and contribute to cancer initiation and progression (i.e., drivers), others emerge simply as victims of genomic instability occurring as a result of cancer progression (i.e., passengers)."
modified 3.5 years ago
3.5 years ago by
mdk • 20