Question: vcf files generated from intersection/union of multiple callers
0
gravatar for lheisler.bioinformatics
4.0 years ago by
Canada

I'm wondering if anyone is aware of a tool that will perform intersections of calls in vcf files and retain all information in the output.  We do look at multiple somatic callers and often want to see which calls are made by both.  

The quick solution is to simply filter the results from one of the callers to remove all records not in the other, but it would be nice to retain header information where it differs as well as Info, Filter, and GT differences.  

eg. if each caller generated a separate DP measure, then final output would have to DP values indicated, perhaps DP1 and DP2

 

 

union intersect merge vcf • 1.6k views
ADD COMMENTlink modified 4.0 years ago by Zev.Kronenberg11k • written 4.0 years ago by lheisler.bioinformatics0
0
gravatar for Zev.Kronenberg
4.0 years ago by
United States
Zev.Kronenberg11k wrote:

For a strict intersection bedtools works well.

ADD COMMENTlink written 4.0 years ago by Zev.Kronenberg11k

Will bedtools generate output in vcf format?  

Sorry if I wasn't clear.  The need is to generate a new vcf file with the intersection or merge, that includes all info from both source files.

ADD REPLYlink written 4.0 years ago by lheisler.bioinformatics0
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1848 users visited in the last hour