Question: Batch correction for TCGA 450K data
gravatar for aditi.qamra
5.1 years ago by
aditi.qamra270 wrote:


When working with Level 3 450K DNA methylation from TCGA, is there a batch correction and/or normalisation that is required ?

1. While downloading the samples from, the samples are listed in batch on applying filters. However I can't find the correct column to identify this batch information in the metadata sheets. Do we need to correct for this ?

2. Does the level 3 data need normalisation across samples ?



tcga dna methylation 450k • 2.7k views
ADD COMMENTlink modified 3.9 years ago by Biostar ♦♦ 20 • written 5.1 years ago by aditi.qamra270

I think you need to correct for batches, have a look [here](

ADD REPLYlink written 5.1 years ago by Ying W4.0k
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