What is the difference between gene signature , disease signature and drug signature?

Question

[ghunt]

As the title suggests I am trying to get a basic understanding of couple of terms gene signature, disease signature , drug signature, gene expression.

Thanks.

Answer 1

[informatics bot]

Disease signature is usually a list of genes, within a specific tissue, that are up or down regulated when compared to healthy controls.

Gene signature is a group of genes in a cell whose combined expression pattern is uniquely characteristic of a biological/cellular/molecular phenotype (i.e. cilia movement, ion transport, etc)

Drug signature is the gene expression response, within a cell, when it's being stimulated with a drug.