Question: What is the difference between gene signature , disease signature and drug signature?
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gravatar for ghunt
3.3 years ago by
ghunt10
ghunt10 wrote:

As the title suggests I am trying to get a basic understanding of couple of terms gene signature, disease signature , drug signature, gene expression. 

Thanks.

genome • 2.5k views
ADD COMMENTlink modified 2.9 years ago by informatics bot570 • written 3.3 years ago by ghunt10
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gravatar for informatics bot
2.9 years ago by
United States
informatics bot570 wrote:

Disease signature is usually a list of genes, within a specific tissue, that are up or down regulated when compared to healthy controls.

Gene signature is a group of genes in a cell whose combined expression pattern is uniquely characteristic of a biological/cellular/molecular phenotype (i.e. cilia movement, ion transport, etc)

Drug signature is the gene expression response, within a cell, when it's being stimulated with a drug.

ADD COMMENTlink modified 2.9 years ago • written 2.9 years ago by informatics bot570
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