Question: Tools to display mutations in a protein's structure
0
gravatar for sviatoslav.kendall
3.7 years ago by
United States
sviatoslav.kendall510 wrote:

I want to graphically display a number of point mutations in a protein graphically. I am aware of protein-structure-predicting tools (https://en.wikipedia.org/wiki/List_of_protein_secondary_structure_prediction_programs) but I have not heard of any tools that exist for displaying multiple mutations on a single protein.

I would ideally like to great an interactive graphic that would allow the viewer to see each mutation's location highlighted on wild-type structure and be able to select one or more mutations then view their predicted impact on the protein's structure. But simply high-lighting the location of a list of mutations with a different color is my primary goal.

protein sequence • 2.0k views
ADD COMMENTlink modified 3.7 years ago by poisonAlien2.8k • written 3.7 years ago by sviatoslav.kendall510
1

Ok, it looks like PyMol can do exactly this and an open-source version is available. For Mac users such as myself, you can install it easily if you follow these instructions which include installing MacPorts

ADD REPLYlink written 3.7 years ago by sviatoslav.kendall510
1
gravatar for poisonAlien
3.7 years ago by
poisonAlien2.8k
Asgard
poisonAlien2.8k wrote:

cbioportals mutationmapper has an option for this. Once you load your mutation data and submit, you can click on 3D structure for interactive 3D structure with mutations highlighted.

ADD COMMENTlink written 3.7 years ago by poisonAlien2.8k
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