Tools to display mutations in a protein's structure
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6.4 years ago

I want to graphically display a number of point mutations in a protein graphically. I am aware of protein-structure-predicting tools (https://en.wikipedia.org/wiki/List_of_protein_secondary_structure_prediction_programs) but I have not heard of any tools that exist for displaying multiple mutations on a single protein.

I would ideally like to great an interactive graphic that would allow the viewer to see each mutation's location highlighted on wild-type structure and be able to select one or more mutations then view their predicted impact on the protein's structure. But simply high-lighting the location of a list of mutations with a different color is my primary goal.

protein sequence • 3.0k views
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Ok, it looks like PyMol can do exactly this and an open-source version is available. For Mac users such as myself, you can install it easily if you follow these instructions which include installing MacPorts

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6.4 years ago
poisonAlien ★ 3.1k

cbioportals mutationmapper has an option for this. Once you load your mutation data and submit, you can click on 3D structure for interactive 3D structure with mutations highlighted.

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