I am trying to do dock by the use of GOLD through Discovery Studio. I successfully run the GOLD operation but unfortunately I couldn't get a single dock (0 poses). I tried to do it several times by changing the different parameters available and also by adjusting GOLD's default parameters as well. Actually, I prepared protein and ligand (both) well before submitting the job (added all hydrogen atoms) and also the receptor site in protein by creating well sphere around the ligand binding site. However, the result's were all the same. But when I tried to do same job by using SOMA2 (which is available in CSC) with same selection of atom as in Discovery Studio I was able to get docking results. I am wondering why couldn't get any doc poses while using DS (GOLD)...any suggestions please?
PS: All the suggestions and help will be highly appreciated!