Hi everyone, I have treated a megaplasmid sequence with RAST annoation tools, and the result return with many hypothetical proteins, is that normal? Is it a good or bad thing? 600 genes out of 756 are hypothetical proteins.
Thanks for reply.
I suggest you to give a look at this article in wikipedia and references within to get started with the world of "hypotetical proteins"!
Good or bad, you ask? It depends. If you characterized a novel "exotic" megaplasmid for which you want to show how many new fucntions it has, it's good. If you are screening a very famous megaplasmid, for which most of the genes are already annotated, it's bad...
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