I'm trying to understand the difference between the coordinate systems of different software: UCSC's
I've a list of SNPs with genomic coordinates in hg18 (based on HapMap3 data) that I'm converting to hg19 using
liftOver. I wanted to verify if all the coordinates and SNPs reported by
liftOver are valid and hence submitted the list of SNPs to dbSNP on browser. But
dbSNP returns coordinates in GrCh38 (hg38) which is their latest build. Hence, I used NCBI's
Remap to map the coordinates to GrCh37 (hg19).
But the coordinates I've from liftOver and Remap are off by 1. For one instance,
chr10 114748496 114748497 rs4074720 and
chr10 114748497 114748498 rs4074720
Is it because dbSNP's coordinate system is 0-based and liftOver is 1-based? I've read posts that mention bed (which was the format I requested from dbSNP) files are 0-based as opposed to other files which can have 1-based coordinate system.
Thanks for your help!