Immune cell specific data

Question

[patvann]

Hello! I am looking for the following:

• B cell specific genes (around 100 or so)
• Monocyte specific genes (around 100 or so)

I am trying to identify B cells and monocytes from single cell RNA sequencing data. I was able to identify T cells using the T cell specific genes named in this article (http://www.ncbi.nlm.nih.gov/pubmed/16339519). However I am unable to find a similar list for B cells and monocytes.

Any and all suggestions welcome. Thanks very much!

Best, Patrick

Answer 1

[natasha.sernova]

I'm not sure they have found about 100 genes for monocytes,

the authors studied different stages of monocyte development:

see the picture and paper below. In particular, "they reported the identification

and characterization of a progenitor of monocytes and

monocyte-derived macrophages. See Figure 8:

http://www.nature.com/ni/journal/v14/n8/fig_tab/ni.2638_F8.html

and the whole paper below:

http://sci-hub.io/10.1038/ni.2638 #

Concerning B-cells.

There were found a lot of B-cell specific genes, again, see the paper below:

http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-7-115

the authors have identified 427 "B-cell signature" genes.

Electronic supplementary material inside the paper does provide a list of genes.