VCF +PDB for protein structure prediction

Question

[srx3001]

Hello!

I have a set of PDB files for small proteins as well as ~600 VCF (mostly SNPs and short indels) files of the members of the same species with certain mutations.

I am looking for a tool that can check the effect of mutations on the protein structure. For example if there is a helix or a strand broken, or if there is a large shift in stability.

I am aware of I-mutant , DUET and SDM, but those only predict structures with a single mutation while I have quite a number of genes with multiple mutations.

Is there a tool that can check the effect of these multiple mutations on the protein structure?

Thank you in advance!