I would like to design a SNP chip to be used in primary care/clinical setting. I have the ability to determine what markers to have on this custom designed chip. This is not going to be focused on a single disease group/phenotype and is meant to be used as a screening test, risk prediction tool and for some known diseases a diagnostic test. I can think of looking up OMIM, ClinVar and HGMD Professional for known disease associated SNPs. Do you have any other suggestions? What should be the best approach for designing a chip like this?