Question: GWAS from case/control + family based WGS data -how to effectively use together
gravatar for Mamta
3.8 years ago by
United States
Mamta450 wrote:

HI all,

We have a GWAS from case/control run on exomechip.

We also have 8 families (not necessarily trios) with affected and unaffected members whole genome sequenced. This is a common disease more prevalent in this ethnic group.

I am hoping to use this familial study as a filter for the exomechip variants before replicating in other in dependent. Iam currently thinking of ways to use this filter - however aim a little concerned that the disease does not have 100% penetrance but sometimes skips a generation and shows up in the next.

Any suggestion how to effectively use the filter or any paper?

Thanks so much!! Mamta

familial variant filter gwas • 1.2k views
ADD COMMENTlink modified 3.8 years ago by natasha.sernova3.7k • written 3.8 years ago by Mamta450

Dear Mamta,

See these papers, I hope, they may be helpful:

ADD REPLYlink modified 3.8 years ago • written 3.8 years ago by natasha.sernova3.7k

Thanks. I will look into them.

ADD REPLYlink written 3.8 years ago by Mamta450
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