Question: How many non-tumor samples needed for survival analysis?
0
gravatar for jzhou
3.3 years ago by
jzhou10
USA, California
jzhou10 wrote:

Hi All, I've been working on my own survival analysis of PDAC, following the tutorial Survival analysis of TCGA patients integrating gene expression (RNASeq) data, but after I separated the tumor and non-tumor samples, I found that there were 179 tumor samples but only 4 non-tumor samples. I don't have too much experience with bioinformatics but I believe that 4 samples does not carry enough statistical weight even though they're normal samples to compare the cancer against and I was wondering if someone could confirm or correct me? If 4 samples is not enough, does anyone know how to find non-tumor samples in other databases like GEO? Thanks

rna-seq • 613 views
ADD COMMENTlink modified 3.3 years ago by EagleEye6.5k • written 3.3 years ago by jzhou10
1
gravatar for EagleEye
3.3 years ago by
EagleEye6.5k
Sweden
EagleEye6.5k wrote:

For survival analysis there is no need for non-tumor samples, it should be carried out only using tumor samples. The non-tumor samples are important when you perform differential expression analysis.

ADD COMMENTlink written 3.3 years ago by EagleEye6.5k

Thanks for a quick reply!

ADD REPLYlink written 3.3 years ago by jzhou10
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