Question: Correcting for multiple testing in Admixture Mapping in Latinos
gravatar for GabrielMontenegro
2.9 years ago by
United Kingdom
GabrielMontenegro520 wrote:

I am doing an admixture mapping analysis on Latino populations.

What I want to know is whether there is a standard? genome-wide threshold for correcting for multiple testing for these populations? Or a reference paper?

I know that the parameter of interest in this case is not the number of SNPs, but actually the number of ancestry blocks in the genome. So, what I first did, was to estimate the number of unique ancestry blocks per population, but this number exceeded 100K in most populations, which would be equivalent to correcting for 100,000 hypothesis. I know that it is not as large as the commonly used 1M hypothesis correction for GWAS, but I wanted to know if there is another method/approach to do this?

Thank you in advance.

admixture gwas genome • 828 views
ADD COMMENTlink written 2.9 years ago by GabrielMontenegro520
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1731 users visited in the last hour