Question: Volcano plot from Posterior probabilities instead of p-value
gravatar for Thibault D.
4.0 years ago by
Thibault D.690
European Union
Thibault D.690 wrote:

Hi !

I'm currently diving into isoforms differential expression analysis results. I use the duo RSem-EBSeq to perform this work. I'd like to build a volcano plot of my data.

RSem-EBseq returns posterior probabilities (PP) and no p-values (PV) at all. I am aware, that both PP and PV allows me to answer the same question. I know that PP goes from 0 the lowest probability to 1, the highest. So I could just multiply those values b -1 to have a volcano plot in the same orientation as a "classic one".

Is it acceptable to do such a thing ?

ADD COMMENTlink written 4.0 years ago by Thibault D.690

It sounds valid to me to use the PP, but I'm not sure what you mean whit "classic one" and orientation.

ADD REPLYlink written 4.0 years ago by WouterDeCoster44k

If I do not multiply by -1, the volcano plot with PP would be reversed horizontally: the maximum value would be 0, the worst PP

ADD REPLYlink written 4.0 years ago by Thibault D.690
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