Candidate Gene Prioritization
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5.6 years ago
nkausthu ▴ 30

It would be really great if someone can give some suggestion on these methods a) The best way to cluster a list of genes based on the information of gene ontology, pathway, sequence, and protein interaction networks? b) Based on these seed genes information how to prioritize new candidate genes?

Seed genes Prioritization Clustering • 1.2k views
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If prioritization is for basic research, and you have limited time for experimental follow-up experiments, prioritization by anticipated biological relevance, and availability of reagents (which ideally had been used to study same genes in another context), might be the right way.

If you want to find some new biology, chances are that domain-knowledge will be better than generic resources that capture (known) biology.

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