Hi everyone, please paraphrase or rephrase these or is there another way to say these?
Intragenomic comparisons allow investigator to infer whether sequences have diverged enough to assume a different function. Whereas intergenomic comparisons allow investigator to identify evolutionarily conserved sequences, genes as well as non-coding regions. Functionally relevant sequences will be conserved.
Comparative genomics helps identify regulatory regions such as promoter binding sites by highlighting areas of high conservation between species. This high conservation indicates an evolutionary purpose to the sequence and implies an important function, even if the sequence is not in an ORF. In general, identification of regulatory regions can be challenging as these sequences are short and can usually tolerate more variation than coding sequences. However, in comparative genomics, alignment with multiple species makes conservation of these elements much clearer, and even beyond the particular species being studied, sequences can be compared to a catalog of known motifs, as was the case in this study.
Any input is appreciated. Thanks a lot!