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7.6 years ago
anju57115
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What might be the possible reasons behind getting poor scores after alignment of two homologous sequences?
What might be the possible reasons behind getting poor scores after alignment of two homologous sequences?
Either the sequences are very divergent (low sequence similarity) or they are not aligned correctly.
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Many homologous sequences (even between closely related species) evolve beyond the point where their homology can be recognized by a simple sequence alignment.