How to clustering people or base pair composition of snps?

Question

[xingshunkai]

Firstly, I have a snp-sets which associate with a particular disease. The snp-sets is filtered by GWAS, reference a bunch of papers(select 3-30 snps). Then I got a snps record came with 1000 sample(there is no phenotype info, only snp type is specific). I wanna clustering thoose data to classify those smaples or classify snp compositions based on the probability.

It may reflect the rank of disease such as: health, medium, heavy or different defect in the complicated pathway

So, how could I do that? Use what kind of Clustering method, probability model? How should I design the dissimilarity matrix?

[xingshunkai]

Data

SNP Annotation

Snp Sample Record

[Jean-Karim Heriche]

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Answer 1

[xingshunkai]

Previous Work

MDS

PCA

Statistic

Venn Graph

Workflow