Question: Genotype normalization: the PLINK --standard-beta flag
1
gravatar for augmntd4th
3.9 years ago by
augmntd4th10
augmntd4th10 wrote:

According to PLINK documentation, the flag "--standard-beta" used for linear regression analysis normalizes all predictors, including the genotype. While I understand the reason behind normalizing the phenotype (such as for comparison with associations of other phenotypes measured at a different scale), I cannot see the rationale behind normalizing the genotype. And I cannot find any information about it. Does anyone have any ideas?

Many thanks.

-Katerina

ADD COMMENTlink written 3.9 years ago by augmntd4th10

For what it's worth, genotype normalization in this context is being removed in PLINK 2.0; standard-beta will only normalize covariates and quantitative phenotypes.

ADD REPLYlink modified 3.9 years ago • written 3.9 years ago by chrchang5237.6k
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