Question: Genotype normalization: the PLINK --standard-beta flag
gravatar for augmntd4th
3.9 years ago by
augmntd4th10 wrote:

According to PLINK documentation, the flag "--standard-beta" used for linear regression analysis normalizes all predictors, including the genotype. While I understand the reason behind normalizing the phenotype (such as for comparison with associations of other phenotypes measured at a different scale), I cannot see the rationale behind normalizing the genotype. And I cannot find any information about it. Does anyone have any ideas?

Many thanks.


ADD COMMENTlink written 3.9 years ago by augmntd4th10

For what it's worth, genotype normalization in this context is being removed in PLINK 2.0; standard-beta will only normalize covariates and quantitative phenotypes.

ADD REPLYlink modified 3.9 years ago • written 3.9 years ago by chrchang5237.6k
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