Question: miRNA-Gene Interaction P-Values
gravatar for ilikebing2000
3.0 years ago by
ilikebing200050 wrote:

Hi everybody,

I searched about 'miRNA-Gene Interaction' Databases through the web to find : A database which each of it's record specifies a miRNA-Gene interaction with the respective p-value of that! I found some sort of it like TarBase, but their weren't what i look for.

Do you know any databases which I can give them a list of miRNAs and the database give me all of the genes which have interaction with the given miRNAs with the respective p-value?


mirna interaction p-value gene • 1.0k views
ADD COMMENTlink modified 3.0 years ago by Ahill1.8k • written 3.0 years ago by ilikebing200050

If you are thinking of statistical significance for predicted miRNA targets, I think you will be disappointed. The error rates of such prediction methods are high and I would not expect that an individual prediction would ever be statistically significant (not because the methods are bad, it is just a hard problem).

ADD REPLYlink modified 3.0 years ago • written 3.0 years ago by Lars Juhl Jensen11k
gravatar for Ahill
3.0 years ago by
United States
Ahill1.8k wrote:

TargetScan provides a database of miRNA-gene interactions including a pCT statistic for the interactions. For human, downloadable from here:

ADD COMMENTlink written 3.0 years ago by Ahill1.8k


Is the concept of P_CT (Probability of Conserved Targeting) similar to p-value (Probability Value in Hypothesis Testing)?

ADD REPLYlink modified 3.0 years ago • written 3.0 years ago by ilikebing200050

Apparently no. The authors say "[the pCT] reflected the Bayesian estimate of the probability that a site is conserved due to selective maintenance of miRNA targeting rather than by chance or any other reason not pertinent to miRNA targeting". So this is definitely not a type I error measure like a traditional p-value. Higher pCT values represent higher confidence sites. Authors do describe pCT as 1 - FDR for predicting "biologically conserved target sites". I would read the methods section in this paper: for details.

ADD REPLYlink written 3.0 years ago by Ahill1.8k
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1039 users visited in the last hour