Question: Which genes or proteins to compare in a phylogenetic tree?
gravatar for crawforc3
3.7 years ago by
crawforc350 wrote:

I am a student and I have a fun problem: My friend doesn't like cats and thinks raccoon's are "way cooler." I want to build a phylogenetic tree and show him that we're more closely related to cats and therefore cats are cooler.

However, my school assignments always told me which gene or protein to use for analyses.

So how do I decide which gene/prot to compare without looking back at old assignments?

I'll be looking at house pets so I know I need something that cats, dogs, lizards, gold fish, and snakes have in common.

What should be my next steps?

evolution gene genome • 800 views
ADD COMMENTlink modified 3.7 years ago by Jean-Karim Heriche23k • written 3.7 years ago by crawforc350
gravatar for Jean-Karim Heriche
3.7 years ago by
EMBL Heidelberg, Germany
Jean-Karim Heriche23k wrote:

Phylogenies using a single gene are not reliable. For this kind of comparison, you should probably use fast evolving genes such as mitochondrial genes. Check the literature, people have most likely already worked out which genes to use and how.

ADD COMMENTlink written 3.7 years ago by Jean-Karim Heriche23k

Why faster evolving genes? Would that make a more apparent differentiation?

ADD REPLYlink written 3.7 years ago by crawforc350

Because you're interested in species which diverged relatively recently i.e. their most recent common ancestors are not old so faster evolving sequences will contain more information.

ADD REPLYlink written 3.7 years ago by Jean-Karim Heriche23k
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