Question: sequences data QC
0
gravatar for chengyi31000
2.7 years ago by
chengyi3100010
chengyi3100010 wrote:

I want to do the QC process for sequence data. But can't not find the relative information. I have done the GWAS QC process like sex check, Genotyping call rate check, Homozygosity check, Cryptic relatedness check, Divergent ancestry check, Remove SNPs with low GCR or MAF and Remove SNPs violating HWE. It's same as sequences?? But I have found that sequences data have much missing call rate for snp.

quality control sequence • 754 views
ADD COMMENTlink written 2.7 years ago by chengyi3100010

It's unclear which data (fastq? bam? vcf?) you have and which QC you want to perform. Please elaborate.

ADD REPLYlink written 2.7 years ago by WouterDeCoster42k

My data is VCF file. I am wondering what process need to do and what's the threshold of remove snp call rate, HWE...etc. Thank you!

ADD REPLYlink written 2.7 years ago by chengyi3100010
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