I'm struggling with finding an example of ISCN notation for  Trisomy 21 as detected by FISH;  Trisomy 21 as detected by microarray, and wondering if anyone can help? Also curious to know if there is publically accessible ISCN validator?
It seems as though ISCN could be very useful - for instance, as an index into dbVAR. But I can't seem to find any ISCN representations on dbVAR. Does anyone have any insight into the greater use of ISCN for helping to query public knowledge stores, particularly for complex / structural variants?