Question: CNA vs mRNA Expression level
0
gravatar for gracie
23 months ago by
gracie10
gracie10 wrote:

Hi,

I am comparing CNA data with mRNA expression level. For some genes there is no correlation between copy number and mRNA expression level and even for some there is negative relation (low copy number yet high mRNA expression). I found some papers stating same situation but I could not find any paper discussing it in a deeper manner. I will appreciate if one can help me to understand this.

thank you

tcga cna • 1.1k views
ADD COMMENTlink modified 19 months ago by igor7.9k • written 23 months ago by gracie10
1
gravatar for bruce.moran
19 months ago by
bruce.moran620
Ireland
bruce.moran620 wrote:

This paper might help, it deals with CNA, mRNA and proteome, and presents an 'attenuation expression signature' for genes that are unaffected by CNV, possibly due to degradation of a rate-limiting complex-partner. Probably goes beyond your scope, but some useful ideas (at least for me!).

ADD COMMENTlink written 19 months ago by bruce.moran620
1
gravatar for arta
19 months ago by
arta540
Sweden
arta540 wrote:

First of all, there is no linear correlation between CNA and mRNA or, mRNA and protein expressions. That is why biology is challenging, there are many other parameters like post transcriptional modification, post translational modification, epigenetics etc.. (some of them we know, some of them are still missing) that we have to take into account.

There are papers that might be interesting for you.

paper 1

paper 2

paper 3

ADD COMMENTlink written 19 months ago by arta540
0
gravatar for igor
19 months ago by
igor7.9k
United States
igor7.9k wrote:

Check this previous discussion on this topic: CNV detection from RNA-seq data

ADD COMMENTlink written 19 months ago by igor7.9k
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