Question: CNA vs mRNA Expression level
0
gravatar for gracie
2.8 years ago by
gracie20
gracie20 wrote:

Hi,

I am comparing CNA data with mRNA expression level. For some genes there is no correlation between copy number and mRNA expression level and even for some there is negative relation (low copy number yet high mRNA expression). I found some papers stating same situation but I could not find any paper discussing it in a deeper manner. I will appreciate if one can help me to understand this.

thank you

tcga cna • 1.6k views
ADD COMMENTlink modified 2.5 years ago by igor10k • written 2.8 years ago by gracie20
1
gravatar for bruce.moran
2.5 years ago by
bruce.moran780
Ireland
bruce.moran780 wrote:

This paper might help, it deals with CNA, mRNA and proteome, and presents an 'attenuation expression signature' for genes that are unaffected by CNV, possibly due to degradation of a rate-limiting complex-partner. Probably goes beyond your scope, but some useful ideas (at least for me!).

ADD COMMENTlink written 2.5 years ago by bruce.moran780
1
gravatar for arta
2.5 years ago by
arta580
Sweden
arta580 wrote:

First of all, there is no linear correlation between CNA and mRNA or, mRNA and protein expressions. That is why biology is challenging, there are many other parameters like post transcriptional modification, post translational modification, epigenetics etc.. (some of them we know, some of them are still missing) that we have to take into account.

There are papers that might be interesting for you.

paper 1

paper 2

paper 3

ADD COMMENTlink written 2.5 years ago by arta580
0
gravatar for igor
2.5 years ago by
igor10k
United States
igor10k wrote:

Check this previous discussion on this topic: CNV detection from RNA-seq data

ADD COMMENTlink written 2.5 years ago by igor10k
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