Question: Duplicate ID in bed file
gravatar for
2.3 years ago by
janhuang.cn150 wrote:

I am using PLINK v1.90b3s 64-bit (17 Jun 2015) to generate a LD matrix from 1000G VCF file for a long list of SNPs.

I use this command to convert VCF to bed file

plink --vcf ALL.chr22.phase3_shapeit2_mvncall_integrated_v5a.20130502.genotypes.vcf.gz --make-bed --out binary_fileset

I then use this command to generate LD statistic reports

plink --r2 --bfile binary_fileset --ld-snp-list snp_chr22_sample.txt --ld-window-r2 0.8

But it returns the below error

Error: Duplicate ID 'rs10656307'.

The SNP file does not contain this SNP. So I think it is the bed file contain duplicated record of rs10656307. Is there a way to remove duplicated SNP in the bed file?

duplicate id bed • 2.4k views
ADD COMMENTlink modified 16 months ago by Sergei Slavskii0 • written 2.3 years ago by janhuang.cn150
gravatar for Floris Brenk
2.3 years ago by
Floris Brenk890
Floris Brenk890 wrote:

Using --list-duplicate-vars you can identify the duplicates in the data plink website identifying duplicates

And using --exlcude you can remove your snps plink website removing snps

ADD COMMENTlink written 2.3 years ago by Floris Brenk890

I used the --list-duplicate-vars to generate a list of duplicated SNPs, but it does not contain the one reported as dulicate in the analysis.

ADD REPLYlink modified 2.3 years ago • written 2.3 years ago by janhuang.cn150

Right, I think --list-duplicate-vars only find SNPs duplicated by position.

ADD REPLYlink written 10 months ago by Phoenix Mu10
gravatar for Sergei Slavskii
16 months ago by
Sergei Slavskii0 wrote:

I had the same problem. Solved in two steps:

1) Got all the duplicated ids from the bim file: cut -f 2 ALL.chr1.bim | sort | uniq -d > 1.dups

2) Excluded these ids from the bfile:

plink --bfile ALL.chr1  --exclude 1.dups --make-bed --out ALL.filt.chr1;

With these new filtered files there were no errors while generating LD reports

ADD COMMENTlink written 16 months ago by Sergei Slavskii0
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