Normalization of NGS data to make CNV calls
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7.3 years ago
caspase8mach ▴ 30

Hi Biostars Community,

I have low-coverage (~ 1X) WGS data for 5 disease and 5 controls samples. I want to make CNV calls using this data.

My question is, do I need to normalize reads for ALL the samples before making CNV calls? If so, could you please suggest an R package to do so!

Thanks a lot for the help.

Best regards, Akhil

R CNV NGS Normalization Reads • 1.7k views
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