Question: Future direction of Gene Set Enrichment Analysis
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gravatar for lmanohara99
15 months ago by
lmanohara9920
Sri Lanka
lmanohara9920 wrote:

Gene Set Enrichment analysis has a quite developed method in the recent past. But existing methods can have pitfalls. I would like to research on GSEA and I need to to know what would be the future direction of this research area.

gsea rna-seq gene • 807 views
ADD COMMENTlink modified 15 months ago • written 15 months ago by lmanohara9920

Sidebar: I think GSEA should be reserved for this method: http://software.broadinstitute.org/gsea/index.jsp

Do others agree? Disagree?

ADD REPLYlink written 15 months ago by Malcolm.Cook850
1
gravatar for The
15 months ago by
The90
United States
The90 wrote:

One important point is correlation between gene expression so independence assumption doesn't hold true. Some methods addressed this issue

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458527/

ADD COMMENTlink written 15 months ago by The90
1
gravatar for nr23
15 months ago by
nr2370
nr2370 wrote:

A good place to start: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-017-1571-6

ADD COMMENTlink written 15 months ago by nr2370
0
gravatar for lmanohara99
15 months ago by
lmanohara9920
Sri Lanka
lmanohara9920 wrote:

Can we take a machine learning based approach for solving the same problem which has been solved by the statistical methods?

ADD COMMENTlink written 15 months ago by lmanohara9920
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