The Basic Science Program (BSP) pursues independent, multidisciplinary research program sin basic or applied molecular biology, immunology, retrovirology, cancer biology or human genetics. Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR). The Microbiome Core undertakes the characterization of microbiome samples by next generation sequencing to determine composition and variation as influenced by immune, genetic, and host health factors. The Microbiome core provides support across a spectrum of processes, from nucleic acid isolation to bioinformations and statistical analysis.
Key Roles/Responsibilities:
Bioinformatics Analyst III
- Will be responsible for computational handling and analysis of Next Generation sequences in multiple output file formats for multiple purposes as part of a team to characterize microbiome samples
- Working knowledge, and demonstrated experience, of phylogenetic reconstruction methods and programs
- Must have the ability to interact, and communicate, effectively with experimentalists in a team-oriented work environment
- Must have the ability to provide leadership, to train, or mentor colleagues
Basic Qualifications:
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a Bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education).
- Foreign degrees must be evaluated for U.S. equivalency
- In addition to education requirements, a minimum of five (5) years of related experience in a research environment with some background in database management and utility programming
- Must have experience with sequence data formats and processing from Next Generation platforms (Illumina, PacBio, etc.).
- Ability to use common bioinformatic programs and databases in the area of automated bioinformatics workflows (e.g. GALAXY)
- Ability to use, maintain, or modify, microbiome, metagenome and metatranscriptome analysis pipelines (e.g. Qiime, Mothur, DADA2, HUMAnN2, MetAMOS, MetaTRANS), and databases (Greengenes, Silva, RDP).
- Ability to establish, maintain, and manage databases for storage of sequence and biosample information (SQL, MYSQL, or other database languages).
- Must be able to program/script in Perl or Python or R, and Shell
- Must have strong working knowledge of bioinformatics tools for sequence identification, evaluation and assembly (BLAST, BOWTIE, BWA, etc.)
- Must have experience in statistical data analysis, evaluation and visualization, including strong working knowledge of statistical software (e.g., R, SAS, Bioconductor), and ability to generate heatplots, cladograms, and other methods of data representation
- Must be able to obtain and maintain a clearance.
Preferred Qualifications:
Candidates with these desired skills will be given preferential consideration:
- Master's Degree
- In addition to the above, candidates with proven familiarity of experimental procedures used in data generation If interested in this position, please go to https://www.leidos.com/careers and enter requisition 644388. Any questions, please reach out to Nora DeLuca at nora.deluca@nih.gov
